Essential Role of Magnesium in Health

The Essential Role of Magnesium in Health: What the Evidence Tells Us

Andy Smith | 03/02/2026

    Magnesium is one of the most abundant minerals in the human body, yet many people don’t meet their needs. This essential nutrient plays a fundamental role in over 300 enzymatic reactions, influencing everything from energy production to bone health.

    Understanding the evidence-based benefits of magnesium supplementation and adequately meeting one’s needs is crucial for both men and women seeking to optimise their health.

    What is Magnesium and Why Is It Essential for Health?

    Magnesium is an essential mineral involved in over 300 biochemical reactions in the body, making it critical for overall health and well-being. It plays a key role in energy production, muscle and nerve function, blood glucose control, and bone health. Evidence shows that adequate magnesium intake supports cardiovascular health, metabolic regulation, and nervous system function. 

    Despite its importance, magnesium deficiency is relatively common due to low dietary intake and increased physiological demands. Understanding what magnesium is and why it is important helps highlight its fundamental role in maintaining long-term health.

    Benefits of Consuming Magnesium in Health

    Cardiovascular Health

    One of the most significant benefits of adequate magnesium intake is its impact on cardiovascular health. Research has consistently demonstrated that magnesium plays a protective role against heart disease and stroke. A large-scale study published in the British Medical Journal found that higher magnesium intake was associated with a reduced risk of coronary heart disease, with each 200mg per day increment in magnesium intake associated with a 22% lower risk (Qu et al., 2013). This is particularly relevant given that cardiovascular disease remains the leading cause of death in the UK.

    Magnesium influences cardiovascular health through multiple mechanisms. It helps regulate blood pressure by promoting vasodilation and reducing vascular resistance. The mineral also plays a role in maintaining normal heart rhythm, with a deficiency linked to increased risk of arrhythmias. For both men and women, maintaining adequate magnesium levels through diet or supplementation may therefore represent an important strategy for cardiovascular disease prevention.

    Bone Health and Osteoporosis Prevention

    Whilst calcium often takes centre stage in discussions about bone health, magnesium is equally vital for maintaining strong bones. Approximately 60% of the body's magnesium is stored in bone tissue, where it contributes to bone structure and influences the activity of osteoblasts and osteoclasts, the cells responsible for bone formation and resorption, respectively (Castiglioni et al., 2013).

    This is particularly important for women, who facean  increased risk of osteoporosis following menopause due to declining oestrogen levels. Research indicates that adequate magnesium intake is associated with higher bone mineral density in both men and women. The National Osteoporosis Society recognises magnesium as an important nutrient for bone health, recommending that individuals ensure adequate intake through diet or supplementation where necessary.

    Metabolic Health and Type 2 Diabetes

    The relationship between magnesium and metabolic health has garnered considerable attention from researchers. Magnesium plays a crucial role in glucose metabolism and insulin sensitivity. Studies have shown that individuals with higher magnesium intake have a reduced risk of developing type 2 diabetes, a condition that affects millions across the UK.

    A systematic review and meta-analysis found that magnesium supplementation improved insulin sensitivity and glycaemic control in people with or at risk of diabetes (Veronese et al., 2016). Given the rising prevalence of type 2 diabetes in the UK, with rates continuing to increase in both men and women, ensuring adequate magnesium intake may represent an accessible preventive measure. The mineral's role in carbohydrate metabolism makes it particularly relevant for those following higher-carbohydrate diets or those with metabolic syndrome.

    Mental Health and Neurological Function

    Emerging evidence suggests that magnesium plays an important role in mental health and neurological function. The mineral is involved in neurotransmitter function and the regulation of the hypothalamic-pituitary-adrenal axis, which governs the stress response. Research has indicated that magnesium supplementation may help reduce symptoms of depression and anxiety, conditions that affect substantial numbers of UK adults.

    A study published in the journal Nutrients found that magnesium supplementation improved symptoms of mild-to-moderate depression, with effects comparable to some conventional treatments (Tarleton et al., 2017). For women, this may be particularly relevant given the higher prevalence of depression and anxiety disorders compared to men. Additionally, some evidence suggests that magnesium may help alleviate premenstrual syndrome symptoms, including mood changes and physical discomfort.

    Sleep Quality

    Many people struggle with sleep quality, and magnesium may offer a natural approach to improvement. The mineral plays a role in the regulation of neurotransmitters involved in sleep, including gamma-aminobutyric acid (GABA). Research suggests that magnesium supplementation may improve subjective measures of insomnia, including sleep efficiency, sleep time, and sleep onset latency, whilst also increasing melatonin levels (Abbasi et al., 2012).

    Meeting Your Magnesium Requirements

    The UK's National Health Service recommends that men aged 19 to 64 consume 300mg of magnesium daily, whilst women in the same age range should aim for 270mg per day. However, national diet surveys suggest that many UK adults fall short of these recommendations.

    Good dietary sources of magnesium include green leafy vegetables, nuts, seeds, whole grains, and legumes. Spinach, almonds, cashews, pumpkin seeds, and black beans are particularly rich sources. For those unable to meet requirements through diet alone, supplementation may be considered, though it's advisable to consult with a healthcare professional before beginning any supplementation regimen.

    What Are the Key Takeaways From the Current Evidence?

    Current evidence consistently highlights magnesium as a vital nutrient for metabolic, cardiovascular, musculoskeletal, and neurological health. Research links adequate magnesium intake to improved blood pressure control, insulin sensitivity, bone density, and reduced risk of magnesium deficiency-related complications. 

    While magnesium benefits are well-supported, dietary intake remains below recommendations for many populations. Food-first approaches are encouraged, with supplementation considered when clinically indicated. Overall, the evidence reinforces magnesium’s essential role in health and underscores the importance of meeting daily magnesium requirements through balanced nutrition.

    What Are the Safety Considerations Around Magnesium Supplementation?

    Magnesium supplementation can be beneficial for individuals with low dietary intake or increased requirements, but safety considerations are essential. Excessive magnesium intake from supplements may cause gastrointestinal side effects such as diarrhoea, nausea, and abdominal cramping. 

    High-dose magnesium supplements may pose risks for individuals with kidney disease, as magnesium excretion can be impaired. Evidence suggests that food sources of magnesium are generally safe, while supplementation should be considered on an individual basis. Consulting a healthcare professional ensures appropriate dosage and reduces the risk of adverse effects.

    Conclusion

    The evidence supporting the health benefits of magnesium intake is substantial and growing. From cardiovascular protection to metabolic health, bone strength to mental wellbeing, this essential mineral influences numerous physiological processes in both men and women.

    Given that many UK adults fail to meet recommended intake levels, paying attention to magnesium consumption through diet or appropriate supplementation represents a practical and evidence-based approach to supporting overall health and wellbeing.

    About the Author

    Aleeza Rosenberg BSc (Hons) MSc (Eating Disorders) RD MBDA is a Highly Specialised Eating Disorders Dietitian with advanced postgraduate training in eating disorders. She is a registered dietitian and member of the British Dietetic Association, with extensive experience supporting individuals with complex eating difficulties using evidence-based, compassionate care.

    Frequently Asked Questions

    What does magnesium do in the body? +
    Magnesium supports over 300 biochemical reactions, including energy production, muscle and nerve function, blood glucose control, and bone health. Adequate magnesium intake is essential for cardiovascular health, nervous system regulation, and maintaining overall metabolic balance.
    What are the symptoms of magnesium deficiency? +
    Common symptoms of magnesium deficiency include muscle cramps, fatigue, weakness, headaches, and sleep disturbances. More severe deficiency may affect heart rhythm, bone health, and blood glucose regulation, particularly in individuals with poor dietary intake or increased physiological demands.
    Who is most at risk of magnesium deficiency? +
    People at higher risk include those with gastrointestinal disorders, type 2 diabetes, high alcohol intake, chronic stress, or restrictive diets. Older adults and individuals with limited dietary variety may also struggle to meet recommended magnesium intake levels.
    Which foods are high in magnesium? +
    Foods rich in magnesium include whole grains, nuts, seeds, legumes, leafy green vegetables, and dark chocolate. Incorporating a varied, balanced diet helps meet daily magnesium requirements and supports overall micronutrient adequacy without relying on supplements.
    How much magnesium do adults need per day? +
    Adult magnesium requirements vary by age and sex, with recommendations typically ranging from 300–420 mg per day. Meeting magnesium needs through food sources is encouraged, with supplementation considered when dietary intake is insufficient or clinically indicated.
    Are magnesium supplements safe? +
    Magnesium supplements are generally safe when used appropriately, but excessive intake may cause gastrointestinal side effects such as diarrhoea. Individuals with kidney disease should avoid supplementation without medical advice, as impaired excretion can increase the risk of magnesium toxicity.
    What is the best form of magnesium supplement? +
    Different forms of magnesium vary in absorption and tolerance. Magnesium citrate and magnesium glycinate are commonly well absorbed, while magnesium oxide may be less bioavailable. The best form depends on individual needs, tolerance, and clinical indication.
    Can magnesium help with sleep and stress? +
    Evidence suggests magnesium plays a role in nervous system regulation and may support sleep quality and stress management. While not a standalone treatment, adequate magnesium intake may contribute to relaxation and improved sleep when combined with good sleep hygiene practices.
    Does magnesium support heart health? +
    Magnesium is important for heart rhythm, blood pressure regulation, and vascular function. Research links adequate magnesium intake to improved cardiovascular health and a lower risk of hypertension, highlighting its role as a key mineral for heart health.
    Should magnesium be taken daily? +
    Magnesium should ideally be consumed daily through food as part of a balanced diet. Supplementation may be appropriate for some individuals but should be tailored to dietary intake, health status, and professional guidance to ensure safety and effectiveness.